4-Hexylresorcinol Inhibits Class I Histone Deacetylases in Human Umbilical Cord Endothelial Cells
نویسندگان
چکیده
Histone deacetylases (HDACs) are key enzymes for post-translational modification and influence on various cellular activities. Thus, HDACs associated with many diseases their inhibitors have clinical significance. Here, 4-Hexylresorcinol (4HR) was studied as an inhibitor class I using the HDAC (HDACi) Trichostatin-A a positive control. The 4HR administered 1–100 μM to human umbilical endothelial cells (HUVECs) expression activity were examined. decreased level of HDAC1, 3, 4, 5 in time dose-dependent manner. also increased acetylated lysine significantly (p < 0.05). Collectively, new that reduced HUVECs.
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ژورنال
عنوان ژورنال: Applied sciences
سال: 2021
ISSN: ['2076-3417']
DOI: https://doi.org/10.3390/app11083486